Abstract
To explore the relationship between expressions of cell adhesion molecules CD44 v6 and E-cadherin (E-cad) and lymphatic metastasis in non-small cell lung cancer (NSCLC). Eighty- seven tissue samples obtained from patients with primary NSCLC were collected in our hospital from Dec., 2007 to Dec., 2012, and the expressions of CD44 v6 and E-cad gene proteins in these samples were detected by immunohistochemical method. In the tissue without lymphatic metastasis, the positive expression rate of CD44 v6 was significantly lower, whereas the normal expression rate of E-cad was notably higher than that with lymphatic metastasis (55.6% vs. 78.4%, 47.2% vs. 21.6%), and both differences had statistical significance (P<0.05). Besides, CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphatic metastasis (P<0.05). The positive expression of CD44 v6 and abnormal expression of E-cad may play a very important role in promoting lymphatic metastasis of NSCLC, with synergistic effect. Hence, detection of CD44 v6 and E-cad expressions is conductive to judging the lymphatic metastasis in NSCLC.
Highlights
As the most essential biological characteristic in malignant tumors, infiltration and metastasis are the leading cause for the deaths of patients with tumors
In the tissue with lymphatic metastasis, both CD44 v6 positive expression rate and E-cad abnormal expression rate were obviously higher than their negative and normal expression rates, with statistical significance (P0.05)
It could been seen that CD44 v6 and E-cad expressions had a significant correlation in the non-small cell lung cancer (NSCLC) tissue with lymphatic metastasis (P
Summary
As the most essential biological characteristic in malignant tumors, infiltration and metastasis are the leading cause for the deaths of patients with tumors. The morbidity and mortality of lung cancer are the highest among malignant tumors all over the world, in which most of them result from infiltration and metastasis (Li et al, 2013; Fei et al, 2013; Huang et al, 2013; Cui et al, 2014; Hou et al, 2014). Relevant studies have revealed that cell adhesion molecules (CAMs) CD44 v6 and E-cadherin (E-cad) are closely associated with infiltration and metastasis in a variety of tumors (Amirghofran et al, 2008; Wendt et al, 2011; Shiwu et al, 2012). In this study, the expressions of CD44 v6 and E-cad in nonsmall cell lung cancer (NSCLC) tissue were detected by immunohistochemical method, and their correlation with the lymphatic metastasis of NSCLC was investigated so as to provide evidences for NSCLC clinical treatment
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