Abstract
BackgroundEstradiol is an important marker of ovarian response to ovarian stimulation in ART cycles. The study tries to find the correlation of serum estradiol on the day of HCG trigger to the number of follicles, the number of oocytes retrieved, and the number of mature oocytes, and also, to correlate estradiol per follicle and estradiol per oocyte on the day of HCG, to the number of oocytes retrieved, and to the number of mature oocytes. It is a cross sectional study using retrospective data.ResultsThe data of 232 patients were analyzed. Our study showed a positive correlation between estradiol levels and the number of follicles (NF) (r = 0.592, p < 0.001), number of retrieved oocytes (NRO) (r = 0.576, p < 0.001), and number of mature oocytes (NMO) (r = 0.554, p < 0.001). E/follicle ratio did not have a significant correlation with NRO and NMO. E/Oocyte ratio had a strong negative correlation with NMO (r = −0.280, p < 0.001)ConclusionsSerum estradiol had a positive correlation with NF, NRO, and NMO. But E/O had a strong negative correlation with NMO. These results indicate that estradiol levels can be used as an important clinical tool in the prediction of oocyte and mature oocyte yield in ART cycles. Reproductive outcome in ART cycles is largely dependent on the number of oocytes and mature oocyte yield. Estradiol levels on the day of HCG appear to strongly correlate with the outcome of ART cycles.
Highlights
Estradiol is an important marker of ovarian response to ovarian stimulation in Assisted reproductive techniques (ART) cycles
We tried to find a correlation between the serum estradiol levels on day of trigger with mature follicles, oocytes, and mature follicles, with the aim of finding out whether estradiol levels can be a clinical tool is assessing oocyte and mature oocyte yield
The ESHRE guidelines for ovarian stimulation state that the addition of estradiol measurements to ultrasound monitoring was neither found superior to ultrasound monitoring alone nor does it recommend the timing of final oocyte maturation trigger based on estradiol or estradiol/follicle ratio as it was not found superior in terms of efficacy and safety than ultrasound monitoring alone [16].The present study found that as estradiol values increased, you could expect more oocytes and mature oocytes, in turn leading to a probably better ART outcome
Summary
Estradiol is an important marker of ovarian response to ovarian stimulation in ART cycles. The study tries to find the correlation of serum estradiol on the day of HCG trigger to the number of follicles, the number of oocytes retrieved, and the number of mature oocytes, and to correlate estradiol per follicle and estradiol per oocyte on the day of HCG, to the number of oocytes retrieved, and to the number of mature oocytes. Estradiol (E2) or 17β E2 is the primary female sex steroid secreted mainly from the granulosa cells of the ovarian follicle.
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