Abstract
BackgroundAllergic rhinitis is a common problem affecting between 20 and 25% of the population lowering the quality of life (QOL) more than any other disease. Dyslipidemia is known to impact potently the development of atopy as it promotes proatopic Th2 immunity and allergic inflammation.ObjectiveThe aim was to test the correlation between severity of allergic rhinitis and dyslipidemia.Materials and methodsA comparative study carried out on 350 allergic rhinitis patients were subjected to full serum lipid assays, visual analog scale assessing their nasal symptoms, and QOL assessment using a seven-point scale.ResultsPatients were divided into two groups (according to their lipid profile): abnormal dyslipidemia group (33%) and normal lipid profile group (67%).The abnormal dyslipidemia group showed a more intense allergic rhinitis symptoms compared with the normal lipid profile with poor QOL score (1.97).ConclusionDyslipidemia might play an important role in increasing the severity of allergic rhinitis symptoms with impaired patients’ QOL; therefore, its control could achieve better treatment outcomes.
Highlights
According to the full lipid profile investigation results, the patients were divided according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III [14] under dyslipidemia and normal lipid profile
Some authors have found that dyslipidemia promotes proatopic Th2 immunity and allergic inflammation [7]
Cholesterol may increase allergen-specific immunoglobulin E (IgE) production, which may in turn aggravate allergic symptoms with correlation between an altered lipoprotein profile and atopy as association has been hypothesized to be due to alterations in the dietary fat intake, a factor possibly contributing to the increase of allergic diseases in industrialized countries [15]
Summary
Allergic rhinitis is an inflammation of the nasal mucous membrane caused by an immunoglobulin E (IgE)-mediated reaction to one or more allergens, clinically manifested as an adverse immune response after repeated contact with usually harmless substances such as pollens, mold spores, animal dander, dust mites, foods, and stinging insects affecting between 20 and 25% of the population [1]. allergic rhinitis is not a life-threatening disease, its burden and economic costs had significantly affected quality of life (QOL) more than any other disease [2].Allergic rhinitis is type I hypersensitivity characterized by sneezing, nasal congestion, nasal itching, and rhinorrhea due to immediately released mediators including histamine, tryptase, chymase, kinins, heparin, leukotrienes, and prostaglandin D2 [3,4].Dyslipidemia, defined as increased serum lipids including triglycerides (TGs), cholesterol, and/or fat phospholipids, is usually noticed with high prevalence in the developed countries due to bad dietary habits and lifestyle [5].Dyslipidemia is known to impact potently the development of atopy by promoting proatopic Th2 immunity and allergic inflammation [6,7].In addition, cholesterol enhances latex-specific IgE and Th2 cytokine production by mononuclear cells of patients with atopy [6]. Allergic rhinitis is an inflammation of the nasal mucous membrane caused by an immunoglobulin E (IgE)-mediated reaction to one or more allergens, clinically manifested as an adverse immune response after repeated contact with usually harmless substances such as pollens, mold spores, animal dander, dust mites, foods, and stinging insects affecting between 20 and 25% of the population [1]. Allergic rhinitis is a common problem affecting between 20 and 25% of the population lowering the quality of life (QOL) more than any other disease. Dyslipidemia is known to impact potently the development of atopy as it promotes proatopic Th2 immunity and allergic inflammation
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