Correlation between DMF-T/def-t and the Secretion of Salivary HBD-1 in carious and non-carious Group of children

Abstract

Background: DMF-T/deft (Decay Missing Filled Teeth) is an index for assessing dental and oral health status, in this case, dental caries. Dental caries is a multifactorial disease with factors namely teeth and saliva, microorganisms, dietary, and time that affecting each other. Human Beta Defensins-1 (HBD-1) is an Antimicrobial Peptides (AMPs) that has a role as an adaptive immune system in oral health, is a factor that affects the susceptibility and development of dental caries that exhibits activity in Streptococcus mutans bacteria. Objective: To prove the relationship between DMF-T/deft and the levels of HBD-1 saliva secretion in the carious and non-carious groups of children. Method: This study was an observational analytic with cross-sectional study design, with the division of 3 groups namely; group 1 (DMF-T/deft = 0, caries-free), group 2 (DMF-T/deft = 1-3, low caries), and group 3 (DMF-T/deft > 6, high caries). Result: DMF-T/deft index (1,000) obtained HBD-1 concentration (-0.451). Low DMF-T/deft index has high HBD-1 concentration, whereas high DMF-T/deft index has low HBD-1 concentration. The value of p < (0.05) showed there was a significant correlation between the DMF-T/deft index with salivary HBD-1 concentrations. Conclusion: There was a relationship between DMF-T/deft and the level of HBD-1 saliva secretion in the carious and non-carious groups of children.