Correlation between Digit Ratio and Incidence of Meningioma and its Clinical Profiles

Hermawan Istiadi,Hexanto Muhartomo,Muhammad Thohar Arifin,Surya Pratama Brilliantika,Tri Indah Winarni

doi:10.3329/bjms.v18i2.40707

Hermawan Istiadi, Hexanto Muhartomo + Show 3 more

Open Access

https://doi.org/10.3329/bjms.v18i2.40707

Copy DOI

Abstract

Background: Proliferation and progression of meningioma were influenced by the balance of estrogen and testosterone. Digit Ratio (DR) was a sign of prenatal exposure to estrogen and testosterone. This study intends to find the relationship between Digit Ratio and meningioma. Aim: To determine the relationship between DR and incidence of Meningioma and its Clinical Profiles (age at the onset, sex, Body Mass Indec (BMI) and histopathology grading) Methods: Analytical observational study was used with case-control design. Case group consisted of patients clinically and histopathologically diagnosed with meningioma (n=25). Patients who were not diagnosed with primary intracranial tumors were included in the control group (n=25). Matched group were conducted. Subjects of this study were patients of RSUP dr Kariadi in the period of January 2016-August 2017. This study was conducted by collecting data consisted of DR, age, sex, BMI, and grading histopathology. Tests used in this study are Chi-Square Test, Mann-Whitney Test and Fishers exact Test. Results: Digit Ratio Mean for right, left and right-left difference were 1.0041; 1.0104 and 0.0357 while for the right and left DR cutoff value 0.993; 0.989. There is a relationship between right and left Digit Ratio and incidence of meningioma (p = 0,000) with OR (Odds Ratio) Right DR = 11.17(CI95% 2,864 – 43,464) and OR left DR = 16,00 (CI95% 4,002 – 63,975). There is a relationship between Right Digit Ratio andBMI case group (p = 0,022). There is no relationship of Digit Ratio and age at onset, gender and histopathology grading (p <0.05). Conclusion: DR is risk factor of Meningioma Bangladesh Journal of Medical Science Vol.18(2) 2019 p.347-352

Highlights

Meningioma is the primary intracranial benign tumor which is originates from the pia tissue and arachnoid 1
Meningioma is associated with high estrogen, progesterone, androgen activity and insulinlike growth factor.[4]
Measurement of Digit Ratio (DR), or more precisely the Secondto-Fourth (2D: 4D) ratio, which is a sign of exposure to testosterone and prenatal estrogen and increased sensitivity to testosterone and esterogen[6]

Summary

Introduction

Meningioma is the primary intracranial benign tumor which is originates from the pia tissue and arachnoid 1. We got cutoff point value for right DR, Left and difference of each digit were 0,993, 0,989, and 0,030. It was concluded that the value of right and left Digit Ratio over the value of cutoff point has a higher risk for experiencing meningioma.

Objectives

Results

Conclusion