Correlation between different blood pressure parameters and coronary artery lesion in patients with primary hypertension

Abstract

Objective To investigate the correlation between different noninvasive blood pressure parameters and coronary artery lesion in primary hypertensive patients. Methods A total of 103 primary hypertension patients who had experienced coronary angiography (CAG) were divided into coronary heart disease group (at least 1 major branch stenosis≥50%, n=55) and normal coronary group (all coronaries were normal, n=48). And the noninvasive arterial pressure and the 24 h ambulatory blood pressure of the two groyps were monitored by artery function test under the same condition. Results Between the two groups, the mean peripheral systolic blood pressure during night, the whole day peripheral pulse pressure, the mean blood pressure fall rate (MBPF) during night and the noninvasive central aortic systolic blood pressure (CSAP), central aortic pulse pressure (CPP), central aortic pulse pressure index (CPPI), noninvasive fraction of central aortic systolic pressure (CFSP), noninvasive fraction of central aortic diastolic pressure (CFDP) were significantly different (P<0.05). The Logistic regression analysis showed that the increases of the noninvasive CPP, CPPI, CFSP and the decrease of CFDP were the risk factors of coronary heart disease (P<0.05). Conclusions The increases of the noninvasive CPP, CPPI, CFSP and the decrease of the CFDP are the risk factors of coronary artery disease, which can be used as the sensitive indexes of early prediction for the primary coronary artery lesion in hypertensive patients. Key words: Primary hypertension; Coronary heart disease; Noninvasive center arterial pressure