Correlation between diastolic dysfunction and global longitudinal strain imaging in patients with diabetes mellitus

Abstract

Introduction and Aim: Diabetes mellitus (DM) is a significant risk factor for cardiovascular diseases (CVD) on its own resulting in left ventricular volume overload which may further impair left ventricular (LV) function. The aim of the study is to evaluate the diastolic dysfunction and global longitudinal strain (GLS) imaging in patients which helps to predict the cardiovascular mortality. Materials and Methods: This study included 45 patients over 50 years with their evidence of fasting blood sugar and PPBS level. E/A, E/E’ and E’ are measured by TDI and Traditional 2D echocardiography; the following parameters are assessed: IVRT, IVCT, pulmonary venous flow and hepatic vein flow. GLS and strain rate were measured in AP4C, AP3C and AP2C views. Results: In our study 93% of patients had normal GLS and 7% of patients had reduced GLS 16% of patients had normal diastolic dysfunction (DD), 68% had grade I DD and 16% of patients had grade II DD. DD does not correlate with GLS in diabetes mellitus patients. Conclusion: According to current guidelines, patients with diabetes mellitus frequently have diastolic dysfunction, but it can also be caused by other reasons. It should be aimed to detect pre-diabetic patients with DD and optimize their clinical management which can be improved by utilizing tissue doppler imaging due to its potential to fill current need for a reliable tool that can demonstrate the effectiveness of therapy in future studies for preventing insulin resistance, DM, and cardiovascular disease.