Abstract
Chronic urticaria (CU) is a common skin disease with complex etiology and pathogenesis, and its cause is unclear in about 80% of patients. In clinic, there are many problems with CU, such as complicated condition, frequent recurrence, poor therapeutic effect of antihistamines, and so on, which seriously affect life quality of patients. In recent years, neuroendocrine-immune system dysfunction has got more and more attention, and has been suggested to play an important role in the pathogenesis of CU. Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEA-S) , which are secreted and regulated by the nervous system, participate in the process of neuroimmune regulation, and are regarded as potential factors regulating immune homeostasis. It has been reported that serum levels of DHEA and DHEA-S markedly decrease in patients with CU. It is unclear whether the decrease of DHEA and DHEA-S circulation concentrations is a primary cause or just a concomitant symptom of CU, and what role it plays in the development of CU. Key words: Dehydroepiandrosterone sulfate; Urticaria; Neuroendocrinology; Incidence; Severity of illness
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