Abstract
The quantitative temporal relationship between changes in CT attenuation, ADC value, and DWI signal intensity of acute ischemic tissue has not yet been determined in an animal model. This study was performed to determine the temporal relationship between CT attenuation, ADC value, and DWI signal intensity in acute cerebral ischemia. CT and DWI were performed at 1, 3, 5, 7, and 9 hours after left MCA occlusion in 11 rats. Mean values for CT attenuation, ADC, and DWI signal intensity were determined for the ischemic hemisphere and contralateral normal hemisphere. Temporal changes in each mean value and the relationship between CT attenuation and ADC value and DWI signal intensity were evaluated. The decrease of CT attenuation and the increase of DWI signal intensity occurred gradually after MCA occlusion, while ADC value decreased rapidly at 1 hour. Although correlation was significant between time and rCT or rDWI (P<.01, respectively), no correlation between time and rADC was found (P=.33). There was a significant linear correlation between rCT and rDWI (r=0.497, P<.01), but no significant correlation between rCT and rADC (P=.509) was found. The temporal change in CT attenuation was different from that in ADC value with no significant linear correlation between CT attenuation and ADC value for acute cerebral ischemia. However, rCT and rDWI showed a modest correlation.
Highlights
AND PURPOSE: The quantitative temporal relationship between changes in CT attenuation, ADC value, and DWI signal intensity of acute ischemic tissue has not yet been determined in an animal model
The extent of CT hypoattenuation or ischemic brain edema is associated with a poor clinical outcome and a risk of brain hemorrhage if the patient is treated with thrombolysis
Relationship between CT Attenuation, ADC Value, and DWI Signal Intensity with Time after MCA Occlusion Figure 3 shows time courses for mean rCT, rADC, and rDWI values after the onset of cerebral ischemia. rCT and rDWI were linearly correlated to time until 9 hours after MCA occlusion with significance (P Ͻ .01, respectively)
Summary
CT and DWI were performed at 1, 3, 5, 7, and 9 hours after left MCA occlusion in 11 rats. The left common carotid artery was exposed through an approximately 3-cm midline incision, performed with the rat in the supine position. The suture was advanced into the left internal carotid artery until resistance was felt, indicating that the tip had passed the MCA origin and reached the proximal anterior cerebral artery. In this way, blood flow to the MCA was blocked by the occlusion of all blood sources from the internal carotid artery and anterior cerebral artery.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
