Correlation Between CRP Il-6 Level, Severity and Mortality in Patients with Covid-19 Infection in Indonesia

Abstract

Background: IL-6 plays an important role in the occurrence of cytokine storm and is the major inducer of C-reactive protein (CRP) gene expression in the liver. This study aims to analyze CRP and IL-6 levels as markers of severity and mortality in COVID-19 patients. Methods: 50 subjects met the inclusion and exclusion criteria; the study was conducted using a retrospective observational cohort design and analyzed using Spearman-Rho and Mann Whitney test. Results: There is relationship between CRP and the severity of COVID-19 with p value < 0.001 and r value 0.604. The severity of IL-6 and COVID-19 was also associated with a p-value of 0.017 and an R-value of 0.337. CRP was also associated with mortality with a p value of 0.004, where the baseline SOFA score was p < 0.001 and the r value was 0.551. IL-6 was associated with symptom onset with a p-value of 0.027 and an R-value of 0.314. Meanwhile, CRP and IL-6 were associated with mechanical ventilation treatment with p-values ​​of 0.013 and 0.027, respectively. CRP also has a strong correlation with IL-6 levels with p value < 0.001 and r value 0.557. Conclusion: Examination of CRP and IL-6 was associated with severity, complications and mortality in COVID-19 patients, except that IL-6 was not associated with mortality because it is influenced by the patient’s comorbid disease.