Correlation between cognitive dysfunction and 5-serotonin receptor 3B subunit in patients with colon cancer after curative resection and its effect on prognosis

Abstract

Objective To investigate the relationship between cognitive dysfunction and the 5-serotonin receptor 3B subunit in patients with colon cancer after curative resection and its effect on the prognosis. Methods From May 2013 to January 2017, 86 patients with colon cancer were retrospectively collected in our hospital. General anesthesia of laparoscopic surgery for colorectal cancer were preformed in all the patients. According to the presence of cognitive dysfunction in the patients after surgery, the patients were divided into a POCD group (cognitive dysfunction, n=28) and a control group (without cognitive impairment, n=58). The data analysis was completed by SPSS22.0. Independent t test was used in the two groups of patients’ mental health. The gene polymorphism analysis of 5-serotonin receptor 3B subunit was analyzed by chi square test. The risk factors of POCD in colon cancer patients after curative resection were analyzed by multiple factor logistic regression analysis. P<0.05 indicated that the difference was statistically significant. Results The polymorphic distribution of rs10789970 was found between the POCD group and the control group, and the proportion of the wild type CC in the POCD group was significantly higher than that of the control group (P 0.05). When compared with the control group, the self-rating anxiety score and self-rating depression score in the POCD group were higher than that of the control group on the third day after the operation (P<0.05). When compared with the control group, the anal exhaust time and hospitalization time in the POCD group were significantly prolonged (P<0.05). Conclusion The occurrence of postoperative cognitive dysfunction in patients with colon cancer after curative resection is related to the polymorphism distribution of rs10789970, which can deteriorate the mental health of the patients and affect the postoperative rehabilitation. Key words: Colonic neoplasms; Cognition disorders; Receptors, serotonin; Rehabilitation; ental status schedule