Abstract
背景与目的肺炎衣原体感染与肺癌有密切关系,但肺炎衣原体感染对肺癌放射性肺损伤的影响尚未见报道。本研究旨在探讨肺癌患者肺炎衣原体(chlamydia pneumoniae, Cpn)IgG阳性对放射性肺损伤相关细胞因子的影响。方法观察有病理诊断、初次胸部放疗肺癌患者69例,分别于放疗前、放疗中和放疗后采血冻存,采用酶联免疫吸附法检测血液中Cpn的IgG以及IL-1β、SP-A、TGF-β、TNF-α的含量。结果69例肺癌患者中Cpn IgG阳性21例,阴性48例,阳性率为30.43%。Cpn IgG阳性组与阴性组放疗中IL-1β浓度分别为(35.82±10.09)ng/L和(30.01±6.46)ng/L,两组之间有差异无统计学意义(P < 0.05),放疗前和放疗后无明显差异。Cpn IgG阳性组与阴性组放疗前SP-A的浓度差异无统计学意义,放疗中分别为(641.78±106.81)ng/L和(100.86±61.4)ng/L,有统计学差异(P < 0.05),放疗后浓度分别(657.47±115.19)ng/L和(93.23±47.15)ng/L,也有统计学差异(P < 0.05)。Cpn IgG阳性组与阴性组放疗前、放疗中、放疗后TNF-α浓度两组之间均无统计学差异。Cpn IgG阳性组放疗前、放疗中、放疗后TGF-β1的浓度分别(710.67±358.16)pg/mL、(1, 002.06±542.16)pg/mL和(2, 125.16±1, 522.29)pg/mL,阴性组分别为(867.77±412.48)pg/mL、(914.05±425.70)pg/mL和(1, 073.36±896.01)pg/mL,两组之间比较放疗后TGF-β1浓度有统计学差异(P < 0.05)。结论肺癌患者Cpn IgG阳性一定程度上提高了放射性肺损伤相关细胞因子SP-A、TGF -β1、IL-1β的水平,提示可能加重肺癌患者的放射性肺损伤。
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