Abstract
Objective:To evaluate the correlation between Central Corneal Thickness (CCT) and Visual Field (VF) defect parameters like Mean Deviation (MD) and Pattern Standard Deviation (PSD), Cup-to-Disc Ratio (CDR) and Retinal Nerve Fibre Layer Thickness (RNFL-T) in Primary Open-Angle Glaucoma (POAG) patients.Methods:This cross sectional study was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from September 2015 to September 2016. Sixty eyes of 30 patients with diagnosed POAG were analysed. Correlation of CCT with other variables was studied.Results:Mean age of study population was 43.13±7.54 years. Out of 30 patients, 19 (63.33%) were males and 11 (36.67%) were females. Mean CCT, MD, PSD, CDR and RNFL-T of study population was 528.57±25.47µm, -9.11±3.07, 6.93±2.73, 0.63±0.13 and 77.79±10.44µm respectively. There was significant correlation of CCT with MD, PSD and CDR (r=-0.52, p<0.001; r=-0.59, p<0.001;r=-0.41, p=0.001 respectively). The correlation of CCT with RNFL-T was not statistically significant (r=-0.14, p=0.284).Conclusion:Central corneal thickness had significant correlation with visual field parameters like mean deviation and pattern standard deviation, as well as with cup-to-disc ratio. However, central corneal thickness had no significant relationship with retinal nerve fibre layer thickness.
Highlights
Glaucoma is the second leading cause of blindness in the world.[1]
Mean and Standard deviation was reported for continuous variables (Age, Central Corneal Thickness (CCT), Mean Deviation (MD), Pattern Standard Deviation (PSD), Cup-to-Disc Ratio (CDR), Retinal Nerve Fibre Layer Thickness (RNFL-T)) while frequency and percentage for nominal/ordinal data
Correlation of CCT with MD, PSD, CDR and RNFL-T is given in Table-II
Summary
Glaucoma is the second leading cause of blindness in the world.[1] It is an irreversible optic neuropathy that has potential sight threatening consequences. All the epidemiological surveys have concluded that the disease is highly underdiagnosed, and most of the patients remain un-diagnosed till later stages, where advanced damage has already taken place.[2] All investigations have been aimed at early diagnosis of this condition to warrant early management and control of associated risk factors. Primary Open Angle Glaucoma (POAG) makes the largest percentage of glaucoma patients, and is the most under-diagnosed condition.[3] Since there is no secondary cause, except genetic predisposition, the condition is usually asymptomatic, with diagnosis only in late stages when irreversible glaucomatous damage has already ensued
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