Correlation between CD8+ T cells′ balance and prognosis for patients with diffuse axonal injury

Abstract

Objective To study the correlation between CD8+ T cells′ balance and prognosis for patients with diffuse axonal injury(DAI). Methods To collect the 41 patients with DAI as observation group, with 33 cases light craniocerebral injury (LCI) patients and 35 healthy volunteers as control group. We detect the peripheral blood CD8+ CD28 + T cells and CD8+ CD28-T cell percentage, and calculate the ratio of both. The subjects working curve method (ROC) of the above CD8+ T cells and its ratio were used to predict the prognosis of patients with DAI efficiency evaluation. Results ⑴ Compared with control group, CD8+ CD28+ T cells in patients with DAI and LCI increased significantly, and DAI was significantly higher than that of LCI group (P<0.05). Compared with control group, CD8+ CD28-T cells in patients with DAI were decreased, but no statistical difference was found between LCI and the control group, but DAI group was significantly lower than the LCI group (P<0.05). ⑵ CD8+ CD28-T cells and CD8+ CD28+ /CD8+ CD28- ratio were correlated with DAI diagnosis (P=0.003, 0.000). When the percentage of CD8+ CD28-T cells =2.95%, the sensitivity of the diagnosis of DAI was 87.49%, 86.21%; When the ratio of CD8+ CD28+ /CD8+ CD28-=7.39, the sensitivity was 92.63%, 90.71%. ⑶ a total of 7 cases of patients died within 1 week after injury, CD8+ CD28+ T cells and CD8+ CD28+ /CD8+ CD28- ratio were significantly negative correlated with survival time (r=-0.739, -0.834, P=0.021, 0.002), and CD8+ CD28-T cells were significantly positive correlated with survival time (r=0.782, P=0.006). Conclusions Decreasing CD8+ CD28-T cells and higher CD8+ CD28+ /CD8+ CD28- ratio in patients with DAI immunological characteristics, especially the ratio (balance) is closely corrected with the diagnosis and prognosis of DAI. Key words: Diffuse axonal injury/IM; CD8-positive T-lymphocytes/ME; Prognosis