Abstract
Membrane fluidity is highly correlated with cellular malignancy, which is involved in cancer metastasis and drug resistance. Although the use of a simple, rapid, convenient, and label-free strategy based on Raman spectroscopy has been reported extensively in the study of membrane fluidity, the systematic studies in tumor tissues are underexplored. Using confocal Raman microscopy in the present study, we collect Raman spectra on the biopsies of high-grade serous ovarian cancer (HGSOC) and normal ovary epithelium, and analyze their membrane fluidities. A multiple immunofluorescence assay based on HGSOCs is used to examine the expression profiles of tumor biomarkers, CD44, a membrane fluidity-associated protein, which supports the conclusions drawn by Raman spectroscopy analysis in the study.
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