Correlation Between CD4, Hemoglobin, and Body Mass Index Levels on The Success of Intensive Phase Therapy among Positive Bacteriological Tuberculosis Patients with Human Immunodeficiency Virus Co-infection

Abstract

Background: Tuberculosis and HIV infections are still a combination of diseases with high mortality rates. The success of intensive phase therapy of positive bacteriological TB patients with HIV co-infection can reduce morbidity and mortality rates. This study aims to determine the relationship between CD4 levels, HB, and BMI on the success of intensive phase therapy among positive bacteriological TB patients with HIV co-infection. Method: This research was an observational analytic study using a retrospective cohort study design conducted in Bali over 5 years (January 2016 to December 2021). Of 120 subjects, 118 subjects met the research requirements. The data was analyzed by Univariate analysis, Bivariate analysis was carried out using Chi-Square, and multivariate analysis was performed using multiple logistic regression. Results: a significant correlation was found between CD4 levels (RR=3,03, p= 0,004), HB (RR= 1,92, p= 0,006), BMI (RR= 5,91 p< 0,001) with successful intensive phase therapy in Bacteriologically Confirmed TB patients with HIV co-infection. All independent variables simultaneously affected sputum conversion (p<0,001; R Square = 0,479; CI: 95%). This study also found that BMI was the dominant predictor that affected the success of intensive phase therapy in Bacteriologically Confirmed TB patients with HIV co-infection (p<0,001; OR: 5,193; CI 95%). Conclusion: CD4, HB, and BMI levels are significantly related to the success of intensive phase therapy in Bacteriologically Confirmed TB patients with HIV co-infection.