Correlation between CD14 and CD163 in duodenal ulcer and gastric cancer patients infected with Helicobacter Pylori

Abstract

Most people around the world are infected with Helicobacter pylori (H.pylori); it can lead to duodenal ulcer (DU) and gastric cancer (GC). The main objective of this study is to determine the correlation between CD14 and CD163 in individuals with DU and GC infected with H.pylori. Sixty nine individuals were included in this work; 27 patients infected with H.pylori only (H.Pylori+), 22 patients infected with H.pylori with DU and 20 patients infected with H.pylori with GC. CD14 and CD163 were measured in all individuals' serum using the Enzyme-Linked Immunoassay (ELISA) test. The results proved there was negative correlation between CD14 and CD163 in H.pylori-positive patients (y= -0.0263x+1.4179). While, there was positive correlation in H.pylori-positive patients with DU (y= 0.0932x+1.6647) and with GC (y= 0.0607x + 1.9824). In conclusion: CD14 and CD163 have a synergistic protected effect in H.pylori-positive patients with DU and GC.