Abstract
1. 1. A study was conducted to determine if actomyosin ATPase (AM) is correlated with cardiac function in three species, rats, dogs, and humans. 2. 2. Mg 2+ stimulated ATPase averaged 0.327 ± 0.031, 0.260 ± 0.026, and 0.180 ± 0.015 and Ca 2+ stimulated activity averaged 0.602 + 0.041, 0.291 + 0.028; and 0.258 + 0.019 μmol/mg/min for rat, dog and human actomyosin samples. Both Mg 2+ and Ca 2+ ATPase were highly correlated with systolic ejection time ( r = −0.99 and −0.90) and maximum heart rate ( r = 0.95 and 0.98). 3. 3. The correlation of an increase in AM ATPase activity with increasing maximal heart rate in different species is of physiological importance to provide adequate perfusion of the heart during diastole.
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