Correlation between Carcinoembryonic Antigen (CEA) Levels and Colorectal Carcinoma Stage Using Computed Tomography (CT) scan : a Study at Dr. Hasan Sadikin Central General Hospital Bandung 2019

Abstract

Background : Colorectal carcinoma (CRC) ranks as the third most common cancerand the fourth most lethal cancer among other malignancy around the world. Carcinoembryonicantigen (CEA) is one of the most common tumor marker used in CRCfor predicting prognosis and therapeutic response. Several studies reported correlationbetween CEA level and the clinical stage of CRC. The determination of clinical stagehas an important role in management planning of CRC. Determination of the CRCclinical stage using Computed Tomography (CT) scan demonstrates good sensitivityand specivicity rates.Objective : To review the correlation between CEA level and the stage of CRC usingCT scan.Methods : This study was of retrospective observational analytic study with crosssectional design. Simple random sampling was used to collect data from availablemedical records and the data were analyzed statisticaly using Spearman test.Results: There were 40 subjects, 24 were men (60%) and 16 women (40%). Theaverage age of the patients was 55,0210,84 and ranged from 28 to 79 year old. Thehighest average CEA level was found in stage IV with a value of 351.26 + 833.65 ng/mland the lowest average CEA level was in stage I with a value of 1.53 + 2.04 ng/ml.The results of the statistical test with Spearman gave a p value of 0.0001 (p <0.05)and a correlation coefficient (R) of 0.588 showed a significant correlation between CEAlevel with clinical stage with a positive correlation direction and moderate correlationstrength.Conclusions : There is a significant correlation between CEA level with clinical stageof colorectal carcinoma using CT scan examination in Dr. Hasan Sadikin GeneralHospital.Key words: Carcinoembryonic antigen (CEA)–clinical stadium–colorectalcarcinoma–Computed Tomography (CT) scan.