Abstract
To investigate the correlation between bursting pressure and breaking strength on the 7th postoperative day following left colonic anastomosis in rats. Seventy rats were randomly divided into seven groups of ten animals each. All of the animals underwent segmental resection of the left colon and end-to-end anastomosis. The animals in groups I to VI underwent surgical laparoscopies with pneumoperitoneums using carbon dioxide or helium at pressures of 5, 12 or 20 mmHg. In Group VII, open laparotomy was performed. The animals were reoperated on postoperative day 7 to measure the bursting pressure and the breaking strength of the anastomosis. The anastomosis bursting pressure in 70 animals was 193.10±55.56 mmHg. There was no significant difference between the groups (p=0.786). The breaking strength of the anastomosis was 0.26±0.12 N. There was no significant difference between the groups (p=0.356). Pearson's correlation test showed a low correlation (r=0.231) lacking statistical significance (p=0.054). There was no correlation between the bursting pressure and breaking strength of left colonic anastomoses in rats on the 7th postoperative day.
Highlights
The ability of the human body to heal a gastrointestinal anastomosis is a fascinating event
Bursting pressure reflects the intestinal anastomosis resistance to an increase in intraluminal pressure, whereas the breaking strength reflects the intestinal resistance to longitudinal forces exerted towards it[2]
The objective of this study was to evaluate the correlation between the bursting pressure and breaking strength of left colonic anastomoses in rats that were subjected to various experimental stimuli
Summary
The ability of the human body to heal a gastrointestinal anastomosis is a fascinating event. The most feared complication is leakage, which results in devastating consequences for the patient and is associated with high rates of morbidity and mortality[1]. Numerous factors can influence anastomosis healing, including bowel preparation, surgical technique, nutritional status, suture tension, manual or mechanical suture use, infection and the use of pharmacological agents[3,4,5]. For the experimental evaluation of intestinal healing, mechanical, biochemical and histological parameters are used[2]. The two experimental mechanical parameters used to assess the anastomosis are the bursting pressure and breaking strength. Bursting pressure reflects the intestinal anastomosis resistance to an increase in intraluminal pressure, whereas the breaking strength reflects the intestinal resistance to longitudinal forces exerted towards it[2]
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