Abstract
Objectives:The aim of this study was to investigate the relationship between Breast Arterial Calcification (BAC) on mammography and the 10-year fatal Cardiovascular Disease (CVD) risk by using SCORE risk system.Methods:The study was conducted from September 2013 to July 2014. A total of 66 women with BAC and 66 age-matched controls without BAC were analyzed. The groups were compared with respect to demographics, clinical, reproductive, laboratory parameters, and 10-year fatal CVD risk.Results:The mean ages of the women in the study was 54.0 years (40-85 years). Hypertension, systolic blood pressure, levels of serum total cholesterol and the calculated SCORE risk were higher in the BAC (+) group than in the BAC (-) group (p=0.04, p=0.031, p=0.046, and p=0.038 respectively). Multivariate analysis showed that none of them was independent factor of BAC on mammograms, only the 10-year fatal CVD risk was close to being statistically significant (OR:1.17, CI:0.98-1.38, p=0.06).Conclusion:BAC on mammography was found to be related to the 10-year fatal CVD risk as calculated by the SCORE risk score system. Additional large-scale prospective studies are required to further assess whether BAC can be considered a useful screening tool for CVD risk prediction in women who screened for breast cancer by mammography.
Highlights
Heart diseases and cancer are the leading causes of death among women in the US, and breast cancer (BC) is the most common malignancy in women.[1]
The Framingham 10-year Coronary Heart Disease (CHD) risk score is a strong predictor of Coronary Artery Disease (CAD), and its relationship between Breast Arterial Calcification (BAC) has been investigated,[5] but to date the estimated 10-year fatal risk of Cardiovascular Disease (CVD) in women with BAC has not been validated by using the SCORE risk system
Multivariate Analysis: The multivariate analysis was performed to determine the relationship of BAC and 10-year fatal CVD risk calculated by the SCORE risk score system
Summary
Heart diseases and cancer are the leading causes of death among women in the US, and breast cancer (BC) is the most common malignancy in women.[1]. SCORE risk estimation system is recommended to calculate 10-year fatal risk of CVD.[8,9] The SCORE system includes age, gender, blood pressure, current smoking status, and total cholesterol levels. The Framingham 10-year Coronary Heart Disease (CHD) risk score is a strong predictor of Coronary Artery Disease (CAD), and its relationship between BAC has been investigated,[5] but to date the estimated 10-year fatal risk of CVD in women with BAC has not been validated by using the SCORE risk system. The aims of this study was to investigate the relationship between BAC on mammography and the 10-year fatal CVD risk by using SCORE risk system
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