Correlation between body mass index (BMI) and the Gleason score of prostate biopsies in Chinese population.

Feng Zhou,Jigen Ping,Jun Ouyang,Yong Lu,Xi Chen,Jinxian Pu,Jianquan Hou,Gang Li,Yong Han

doi:10.18632/oncotarget.11453

Abstract

We assessed the correlation between BMI and Gleason score in prostate biopsies in Chinese Population. In this retrospective study, we collected the Gleason score, PSA, BMI, age, race, and other related clinical data on 290 patients who had undergone prostatic biopsy. We then compared the prostate cancer detection rates and Gleason scores between the high BMI group (BMI ≥ 25; 143 cases) and low BMI group (< 25; 147 cases). Among the 137 patients in whom prostate cancer detected, 70 had high BMIs and 67 had normal BMIs, making the detection rates 48.95% and 45.58% respectively. Seventeen prostate cancer patients had low Gleason scores (Gleason score < 7), while 120 had high Gleason scores (≥ 7). Within the high BMI group, 44.76% had high Gleason scores, which was significantly greater than the 38.10% in the low BMI group (P = 0.027). These results indicate that while there was no effect of BMI on the rate of positive prostate cancer biopsies, the rate of high Gleason scores was greater in the high BMI group than the normal BMI group.

Highlights

Prostate cancer (PCa) is the most common malignant tumor of the male urinary system
Within the high Body mass index (BMI) group, 44.76% had high Gleason scores, which was significantly greater than the 38.10% in the low BMI group (P = 0.027)
These results indicate that while there was no effect of BMI on the rate of positive prostate cancer biopsies, the rate of high Gleason scores was greater in the high BMI group than the normal BMI group

Summary

Introduction

Prostate cancer (PCa) is the most common malignant tumor of the male urinary system. The mortality rates for PCa have increased globally, except in a few high-income countries such as United States [1,2,3]. With the popularization and application of prostatespecific antigen (PSA) screening, a growing number of patients are receiving prostate needle biopsies to confirm PCa. Body mass index (BMI) is an independent risk factor for hypertension, diabetes and coronary heart disease, among others [4,5,6,7]. To investigate the relationship between PCa and BMI, between February 2012 and January 2014, we measured the BMIs of 290 patients at our hospital and assessed the clinical significance of BMI with respect to prostate biopsy in Chinese Population

Methods

Results

Conclusion