Abstract
We investigated the kinetic effect of pioglitazone on changes of body mass index (BMI), body weight (BW), lipids and insulin resistance (IR) in patients with type 2 diabetes mellitus. Materials and method: 24 patients with type 2 diabetes were randomly selected using fasting blood glucose (FBS) > 7 mmol/L (126 mg/dL) in one occasion if the patient is symptomatic, or in two occasions if the patient is asymptomatic. Patients were treated with 15 mg of pioglitazone (PIO) daily and investigated for BW , BMI, FBS, fasting insulin (FI) & triglycerides (TG). IR was calculated by McAuley (McA), HOMA & QUICKI indices at baseline and repeated after 3
Highlights
Incidence of type 2 diabetes is reaching epidemic proportions globally, in south Asian region
There was no significant difference of body mass index (BMI) (23.95 0.82 kg/m2 to 24.08 0.85 kg/m2), body weight (BW) (58.78 2.00 kg to 59.08 2.00 kg) and TG (1.82 0.08 mmol/L to 1.7 0.05 mmol/L) after 3 months
There was a significant reduction in fasting insulin (FI) (37.58 6.09 to 15.37 3.28 mmol/L) FI ( (mU/L)) and insulin resistance (IR) by McA (4.68 0.25 to 6.18 0.31) with PIO treatment (p
Summary
Incidence of type 2 diabetes is reaching epidemic proportions globally, in south Asian region. Type 2 diabetes is characterised by presence of IR and relative insulin deficiency, early identification is important for the management strategies of DM [1,2,3]. The accumulation of visceral fat is assumed to play an important role in the aetiology of IR notably by the overexposure of the liver to free fatty acids [6], which results in insulin resistance and hyperinsulinaemia [1,2,7]. Identification of correlation of (PPAR-) agonists with the obesity the BMI is necessary to develop public health policy and dietary and physical activity recommendations that are both comprehensive and effective in reversing the current trend
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