Abstract
Objective: This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproteinase-2 (MMP-2) expression in patients with prostate adenocarcinoma. Material & method: Prostate cancer patients’ data from January 2009 to May 2012 were collected at the Department of Pathology, Soetomo General Hospital Surabaya. Data collected included patient medical documents, PSA blood examination, and histopathological examination. Histopathology slides and paraffin blocks of needle biopsies, Transurethral Resection of Prostate (TURP) and radical prostatectomy of prostate cancer patients werere-read, then the samples that met the inclusion criteria were stained by immunohistochemistry using antibodies MMP-2. Results: Data collection was done to obtain data samples of prostate cancer patients in 2009 to 2012 comprising as many as 22 patients between the ages of 52-91 years. Prostate adenocarcinoma in age of 70-79 was found in 8 patients, with a mean age of 68 years. PSA values obtained from medical documents were between 8.6-594.41 ng/ml. Spearman's test performed in this study showed a positive correlation (one-tailed) (correlation coefficient (r) 0431, p < 0.05) between blood PSA level and MMP-2 expression in patients with prostate adenocarcinoma. Conclusion: Blood PSA level correlates positively with MMP-2 expression in prostate adenocarcinoma.
Highlights
CORRELATION BETWEEN BLOOD SERI]M Prosrate Specifc Antigen (PSA) LEVELAI{D Morrit Metolloproreinase-2 (MMP-2) IN PROSTATE ADENOCARCINOMA 'Anny Setijo Rehelu, 'Aniek Meidi, 'Gondo Mestutik, 'sjrhjenny Mustokoweni, 'Arifr Musdka
Radicol prosrotectomy of Wstale cdncer patien s were,e-read, lhen the samples lhal et,he inclusion criteia were stairred by imnunohist@hernistry using orltiMies Matrix Metalloproteinase (MMP)-2- I,aul&,: Dala callecrior, was done ao obtain data sarnples of pmstab cancer patienb in 2(n9 b 2012 co prising os maty as 22 Wtients between lhe ages of52-91 years
The aim of this study was to prove the correlation between blood serum PSA level and MMP-2 in prostate adenocarcinoma, since studies on the correlation betryeen blood serum PSA levels and MMP-Z expression in prostate adenocarcinoma is rare
Summary
CORRELATION BETWEEN BLOOD SERI]M PSA LEVELAI{D MMP-2 IN PROSTATE ADENOCARCINOMA 'Anny Setijo Rehelu, 'Aniek Meidi, 'Gondo Mestutik, 'sjrhjenny Mustokoweni, 'Arifr Musdka. Objcaiw: Thb study aims to p.ty ,he conelation berweet Prustote Specific Aatiget @SA) blod level ond Mauit. January 2U) to May 2012 *cte collectd ot the Department of Pathologt, *rctomo collected incldd polient medical dewe .s, PSA bl@d examinatio and General Hospital hisropalhologicol exzmihotion. Spearmarr's tes, pe{ormed in this study shoi,ed a posilive correlation (onetailed) (colrelation coefrcierrr (r) U3 I , p < 0.05) between blood PSA lewl and MMP-2 expession in porien s with prwrste adenocarcinomo. Conclusio|: Rlood PSA level conelates positivelywith MMP-2 expressioa in pmstale odenocarcinoma-
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