Correlation between biological activity and energies of electronic transitions in benzodiazepines. Negative ion mass spectrometry and ultraviolet absorption spectroscopy study of some derivatives.

Abstract

A correlation between the energies of electronic singlet transitions in benzodiazepines and their biological activity, which was revealed earlier by means of negative ion mass spectrometry with resonance electron capture, has been verified with a UV absorption spectroscopy investigation. Also, it has been noted that the energies of electronic singlet transitions in benzodiazepines are close in value to the ionization energies of atoms Cs, Rb, K, Na, Li and Tl, the cations of which are known to play an important role in nerve cell excitation processes. Copyright 1999 John Wiley & Sons, Ltd.