Correlation between biofilm formation and antibiotic susceptibility pattern in Acinetobacter baumannii MDR isolates retrieved from burn patients

Abstract

Biofilm formation is a feature that results in the retention of A. baumannii in the attendance of antibiotics and great stresses. This research was performed to evaluate antibiotic resistance pattern, and the correlation between biofilm formations with antibiotic resistance in A. baumannii retrieved from wound infections of burn patients.International biomedical databases such as Scopus, PubMed, and Web of Science, and Google Scholar and also National databases were sought for cross-sectional research works that assessed the mutual relation between biofilm production and antibiotic resistance in A. baumannii isolates based on PRISMA protocols from January 2005 up to 31th December 2019. The search strings was done using following Medical Subject Headings)Mesh) terms: “Acinetobacter baumannii” OR “A. baumannii” AND “antimicrobial drug resistance” OR “Antibiotic resistance”, OR “drug resistance” AND “Biofilms” OR “biofilm formation” AND “burns” OR “burn” OR “burn unit” OR “burn ward” AND “Iran”. Comprehensive meta-analysis (CMA) software was used for statistical analyses.The pooled Biofilm formation rate was 90.5% (95% CI 79.4–95.9). In fact, 51.1%, 24.5%, and 25.8% of isolates were strong, mild, and weak producers of biofilm. The combined prevalence of MDR isolates was 49.8%. The highest pooled antibiotic resistance of A. baumannii was against Cefotaxime (98.1%) followed by Gentamicin with a resistance rate of 96.1%.Our findings showed that over 90% of A. baumannii strains are capable of producing biofilms, which have a significant role in the development of antibiotic resistance in the burn unit. Therefore, effective strategies must be adopted to counteract this.