Correlation between ApoE gene polymorphism and atrial fibrillation

Abstract

Objective The correlation between ApoE gene polymorphism and the occurrence of atrial fibrillation was speculated based on the inflammatory mechanism. The high-risk alleles of ApoE atrial fibrillation were searched according to the distribution differences of genotype frequency and allele frequency. Methods From January 2017 to January 2019, 64 cases of patients with atrial fibrillation (including paroxysmal, persistent, long-term persistent, and permanent) in the department of cardiovascular medicine of our hospital and 49 cases of healthy outpatient volunteers were selected for the detection of ApoE gene polymorphism by allele polymerase chain reaction (PCR). Statistical analysis was performed to search for high-risk ApoE alleles. Results A total of 113 cases were enrolled in this study. Among them, there were 38 cases of male and 26 cases of female in 64 patients of the atrial fibrillation group, with an average age of (74.38±8.37) years old. There were 29 cases of male and 20 cases of female in 49 cases of the control group, with an average age of (65.24±12.14) years old. The rate of 6 kinds of phenotype of ApoE gene e2/e2,e2/e3,e2/e4,e3/e3,e3/e4,e4/e4 were 0.9%, 13.3%, 2.7%, 58.4%, 19.5%, 5.3%. The population with ApoE protective genotype, general genotype, and risk genotype accounted for 14.2%, 61.1%, and 24.8%, respectively. There were no statistically significant differences in gender, height, weight, smoking, hypertension, type 2 diabetes, and coronary heart disease between the two groups (P>0.05), there were statistically significant differences in age, BMI, LAD, and LVEF (P<0.05). The observed genotype frequency values were consistent with the Hardy-wenberg genetic balance and were representative of the population. Conclusion There is a certain correlation between ApoE gene polymorphism and the occurrence of AF, and ApoEe4 is a high-risk genotype of AF. Key words: Atrial fibrillation; ApoE; Gene; Polymorphism; Inflammatory mediators; Blood lipid; Correlation; Arteriosclerosis