Abstract
Introduction: Polycystic Ovary Syndrome (PCOS) is characterized by clinical and biochemical hyperandrogenism, polycystic ovarian morphology, altered gonadotropin secretion, insulin resistance and /or hyperinsulinemia associated with obesity. Objective: The objective of this study was to compare the correlations between levels of FSH, LH, estradiol, Anti-Mullerian Hormone (AMH), and antralfollicle numbers in women with polycystic ovary syndrome. Methods: PCOS was diagnosed when at least two out of the three parameters were present, according to the Rotterdam criteria. Patients were grouped according to the presence of oligomenorrhea and amenorrhea. Levels of AMH, FSH, LH and Estradiol were determined and a transvaginal ultrasound was performed to determine ovarian volume and the number of antral follicles. Results: Pearson’s correlation revealed a significant correlation (0.283, p =0.01) between AMH and antralfollicle number. It was appetent that the higher the number of antral follicles the concentrations of AMH is also higher. A linear correlation showed that the AMH concentration and the number of antral follicles correlated positively (r =0.303, p =0.002). While the levels of FSH correlated negatively with the number of antral follicles(r = -0.182, p = 0.05).The ovarian volume also correlated positively with the number of follicles (r =0.708, p = 0.000).
Highlights
Polycystic Ovary Syndrome (PCOS) is characterized by clinical and biochemical hyperandrogenism, polycystic ovarian morphology, altered gonadotropin secretion, insulin resistance and /or hyperinsulinemia associated with obesity
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women with a prevalence of 6%–18%1, which is characterized by clinical[2] and biochemical hyperandrogenism, polycystic ovarian morphology, altered gonadotropin secretion, insulin resistance and/or hyperinsulinemia associated with obesity.[3,4]
When the women in the current study were classified according to their menstrual cycle into oligomenorrhea and amenorrhea (Table 2) it was found that follicle-stimulating hormone (FSH) andLH concentrations were significantly higher in amenorrhea patients (p=0.024 and p=0.028, respectively)
Summary
Polycystic Ovary Syndrome (PCOS) is characterized by clinical and biochemical hyperandrogenism, polycystic ovarian morphology, altered gonadotropin secretion, insulin resistance and /or hyperinsulinemia associated with obesity. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women with a prevalence of 6%–18%1, which is characterized by clinical[2] and biochemical hyperandrogenism, polycystic ovarian morphology, altered gonadotropin secretion, insulin resistance and/or hyperinsulinemia associated with obesity.[3,4]. Menstrual disturbances commonly observed in PCOS include oligomenorrhea and amenorrhea. About 70%–90% of women with oligomenorrhea have PCOS while 30%–40% of women with amenorrhea could have PCOS6. Women with PCOS often seek care for menstrual disturbances, clinical manifestations of hyperandrogenism, and infertility. PCOS is the most common cause of anovulatory infertility.[9] Women with PCOS are likely to have a higher antral follicle count (AFC) and a greater ovarian volume.[10]
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