Abstract
Ethanol was found to exhibit anticonvulsant activity in nontoxic doses as measured by four of six well-standardized methods. The effective dose of ethanol, as determined by the various tests, was found to be linearly related to its plasma concentration. The initial increase in low-frequency electroshock seizure threshold, induced by a single large dose of ethanol, was followed by a significant decrease. The central nervous system tends rapidly to accommodate to the ethanol milieu so that the electroshock seizure threshold does not exactly parallel the plasma ethanol concentration. The significance of these observations is discussed.
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