Abstract
Background: To find out the correlation between anti-ds DNA, complement components C3, C34 and disease activity in SLE. Material and Methods: This cross-sectional study was undertaken over a period of 6 months from January 2016 to June 2016 at a Tertiary Care Centre in South India. Blood samples were collected from 100 patients with active lupus, 100 patients with inactive disease and 100 healthy controls. Serum samples from all the 300 samples were tested for anti- dsDNA by ELISA and C3, C4 by Radial Immunodiffusion. Results: High titre anti-dsDNA was detected in 48 out of the 100 patients with active disease. Mean SLE disease activity index (SLEDAI) of patients with high titre anti-dsDNA was 23.08337 ± 3.80276 (P<0.001) Mean SLEDAI of patients with very low C3 and C4 was 21.4314 ± 4.88776 (P<0.001) and 21.1250 ± 4.82882 (P<0.001). Conclusion: Anti-dsDNA, C3, C4 levels can be adopted as markers of disease activity in SLE. Anti-dsDNA by ELISA is a simple and cost effective method. Radial immunodiffusion can be done for C3 and C4 assay where nephelometer is not available as the procedure is simple.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
