Correlation between Angiopoietin-2 and IL-6 as inflammation biomarkers on the severity of coagulopathy and mortality in vasodilated shock patients

Abstract

Background: Sepsis and vasodilatory shock are serious medical conditions and cause high mortality rates worldwide. It is known that IL-6 and angiopoietin-2 levels have a role in the etiology of shock in ICU patients. Consequently, this research aims to examine the involvement of angiopoietin-2 and IL-6 in the severity of coagulation problems in patients with vasodilatory shock. Methods: The study's design is observational analytic with a cross-sectional study design, and the data came from those treated in the ICU room and the Emergency Room at RSUD Dr. Soetomo Surabaya from February 2020 to March 2022. Data collected included age, respiratory rate, DIC score, APACHE II score, mortality, IL-6 levels, and angiopoietin-2 levels. The data was then analyzed using Easy R (EZR). Result: 27 of the 44 patients (61.4% of the total) belonged to the DIC group. A correlation between IL-6 levels and DIC incidence and mortality at first ICU admission and after 24 hours in the ICU was shown to be significant (p<0.05). There was also a significant correlation between Angiopoietin-2 and both DIC incidence and mortality upon admission to the ICU and after 24 hours in the ICU (p<0.05). It was found that the test specificity and sensitivity of Angiopoetin-2 and IL-6 levels on the severity of coagulation disorders and mortality in patients with vasodilatation shock were 85.9% for Angiopoetin-2 and 71.6% for IL-6. Conclusion: There is a correlation between the severity of coagulation disorders in vasodilated shock and increased IL-6 and angiopoietin-2. IL-6 and angiopoietin-2 were to be correlated with mortality and Angiopoietin-2 has higher specificity and sensitivity than IL-6. Multicenter prospective studies are needed to confirm study results.