Abstract
Abstract Objective To carry out a detailed investigation of the impact of aneuploidy on blastocyst quality. Methods 1 257 cleavage-stage embryos from 203 patients underwent IVF treatment with aneuploidy screening were investigated. Comprehensive chromosome analysis involved the use of microarray comparative genomic hybridisation (aCGH) method on single blastomere biopsied on day 3 of embryo development. Embryo morphology was assessed and recorded on days 3 and/or 5–6 post-fertilisation. Morphologic grade A-C was assigned to the blastocysts with grade A being the highest grade and grade C the lowest. Results Among the 1 257 embryos that were analyzed, 474 (38%) were euploid, and 783 (62%) were aneuploid. 315/474 (66.5%) of euploid embyos developed into blastocysts, while 57/783 (32.8%) of aneuploid embryos grew to blastocysts ( P Conclusion Blastocyst morphology showed a significant link to aneuploidy ( P
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