Abstract
Objective To explore the association between acute ischemic stroke and albumin to creatinine ratio (ACR). Methods A case-control study. During January to December in 2013, 127 acute ischemic stroke patients as case group and 150 controls who were similar with case group in age and gender were recruited in Tianjin Union Medicine Center. According to diabetes, hypertension, cardiovascular diseases and patients without these three diseases, case group was divided into A1, B1, C1 and D1 subgroups, control group was divided into A2, B2, C2 and D2 subgroups in the same way. The first morning urine from participants were collected. Urinary albumin concentration was tested by nephelometry, urinary creatinine was examined by using enzymic method, ACR were calculated(≥ 30 mg/g as the cutoff value). Then difference of ACR between case and control group was compared, the cutoff value of albuminuria for ischemic stroke patients was analyzed by ROC, and the risk factor of ischemic stroke were analyzed by logistic regression analysis. Results The prevalence of albuminuria in ischemic stroke patients was 38.58%(49). According to analysis of covariance, after adjustment for age, gender, cardiac-disease, diabetes, hypertension, lnACR in case group was significantly higher than control group (3.18 mg/g vs 2.78 mg/g, t=2.13 P=0.03), especially D1 was significantly higher than D2 subgroup (3.01 mg/g vs 2.51 mg/g, t=5.56, P=0.009). If 19.82 mg/g from ROC analysis was used as the cut-off value, the sensitivity and specificity are 68.5% and 61.7%. The odds ratio (OR) of ACR>19.82 mg/g was about 2-fold when compared with ACR<19.82 mg/g adjusted for stroke risk factors, and the OR value is 2.43 in comparison of patients without diabetes, hypertension and cardiovascular diseases. Conclusions Urinary albumin excretion is the independent risk factor of ischemic stroke. The increased urinary albumin has important clinical significance to predict the risk of ischemic stroke for the patients without diabetes, hypertension and cardiovascular diseases.(Chin J Lab Med, 2015, 38: 457-460) Key words: Brain ischemia; Stroke; Albuminuria; Creatinine; Urinalysis; Risk assessment
Published Version
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