Correlation between β2- Microglobulin and MIA Syndrome in Chronic Hemodialysis Patients

Abstract

Hemodialysis is a treatment that filters waste and water from the blood. Nonetheless this treatment has multiple side effects, such as producing Beta 2 micro globulin, inflammatory aftermath, in addition to changes to the lipid balance (hypertriglyceridemia+ reduction in cholesterol levels HDL) involved in the genesis of long term complications known as MIA syndrome (Malnutrition, Inflammation, Atherosclerosis). In this multicenteric cross-sectional study we gathered 135 patients (average age 52 years old, with average dialysis duration of 9 years and extremes from 1 to 21 years). The results of our study showed that the longer the hemodialysis treatment duration the higher the levels of Beta 2 micro globulin. After detailing the clinical and Para clinical results of the patients, 19% presented with malnutrition, 47% exhibited an inflammatory condition, and 51% were diagnosed with atherosclerotic damage). Our results as well indicate that a high serum level of this protein could have a role in the development of cardiovascular and atherosclerosis complications patients.