Abstract

Type 2 diabetes is a very common type in diabetes, which is also called noninsulin-dependent diabetes. This paper focuses on the correlation between type 2 diabetes (T2D) and aging from the perspective of oxidative stress (OS), including the pathway that T2D produces oxidative stress and the effect that oxidative stress imposes on T2D. This paper also mentioned some specific mechanisms, like a glycolytic pathway, enhanced formation of advanced glycation end products (AGE), activation of protein kinase C (PKC), and deactivation of the insulin signaling pathway. In addition, this paper also talks about the important influence of OS in the process of aging. And, the attention was focused on the excessive ROS produced by mitochondria. On this basis, this paper sorts out the correlation between aging and T2D in OS and finds some experimental evidence, through which this paper also offers some enlightenment from the way of anti-aging to anti-diabetes.

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