Abstract
Objective To assess the correlation between sleep quality and disease activity in rheumatoid arthritis (RA) patients by comparing the sleep quality of RA patients with healthy control group. Methods One hundred and sixty cases of RA patients who were hospitalized in the Second Hospital of Shanxi Medical University from January 2015 to June 2017 were included into this study, and 90 age and gender matched healthy people were selectedas control group. Age, sex, therapeutic drugs, Pittsburgh Sleep Quality Index (PSQI), serum erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the 28-joint Disease Activity Score (DAS28), Visual Analogue Score (VAS) and Beck Depression Inventory second edition (BDI-Ⅱ) were detected and compared. According to the DAS28 scores, the relationship between the sleep quality of RA patients and the degree of disease activity was analyzed. Results One hundred and nine cases (68.1%) with sleep disorders in the RA group, which was higher than that in the healthy control group, in which 17 cases (18.9%) had sleep disorder. The total scores of the PSQI in the RA group were higher than those in the healthy control group, which were (7.2±3.2) scores vs (3.1±2.8) scores (t=10.636, P 5) (56±12) years was higher than that of patients without sleep disorders (48±9) years (PSQI≤5). The VAS and BDI-Ⅱ score in RA patients with sleep distur-bance were higher than those with non-sleep disturbance, which were (5.8±2.2) scores vs (25.1±9.1) scores vs (2.1±2.1) scores vs (14.2±6.6) scores (P<0.05) respectively. According to the results of Pearson correlation an-alysis, DAS28 was significantly positively correlated with BDI-Ⅱ (r=0.382, P=0.001), PSQI wassignificantly positively-correlated with BDI-Ⅱ (r=0.312, P=0.001). Subjective sleep quality, sleep time, sleep efficiency, sleep disorder, daytime dysfunction and the PSQI total score increased with the increase of RA activity. Conclusion The incidence of sleep disturbance in RA patients is higher than that in the normal population. The incidence of sleep disturbance, increases significantly accompanied by high disease activities in RA patients. Key words: Rheumatoid arthritis; Sleep disorder; Disease activity
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