Abstract
Objective To analyze and assess the risk factors affecting acute lymphoblastic leukemia in children, then to improve survival and long-term quality of life using individual treatment programs for children. Method This article used retrospective study. 200 children with newly diagnosed acute lymphoblastic leukemia admitted into our hospital from May, 2012 to March, 2016 were selected as research objects. The clinical data were collected; and the association of various prognostic factors and changes of risk stratification were analyzed. Results The induction therapy complete remission rate of the 200 cases of acute lymphoblastic leukemia was 95.5% after the stratification of risk and related treatment. WBC ≥50 × 109/L at initial treatment, prednisone-induced insensitivity, age > 9 years old and 5% on the 33rd day of induction, BCR/ABL and MLL/AF4 fusion gene positive were the risk factors increasing recurrence and mortality. Conclusion The age at initial treatment, peripheral white blood cell count, fusion gene, chromosomal abnormalities karyotype and translocation, CNS status, the treatment of morphological reactions, and minimal residual lesions are the long-term risk factors affecting the prognosis of children with acute lymphoblastic leukemia. Key words: Children; Acute lymphoblastic leukemia; Risk stratification; Risk factors; Prognosis
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