Correlation analysis of parameters of cardiointervalography and immune status in patients with ischemic stroke depending on the affected area (P1-4.007)

Abstract

<h3>Objective:</h3> To conduct a correlation analysis of cardiointervalography and immunogram parameters in patients with ischemic stroke depending on the location of the ischemia <h3>Background:</h3> The rates of the immunogram and level of autonomic regulation can be used as an additional criterion for autoimmune disorders, assessing the severity of the condition and predicting infectious and inflammatory complications <h3>Design/Methods:</h3> 52 patients with ischemic stroke divided into 3 groups. The I group stroke in the left middle cerebral artery, II–right middle cerebral artery, III-vertebrobasilary basin. Subpopulations of CD3+, CD4+, CD8+, CD16+, CD19+, as well as Interleukin-1β, Interleukin-4, Interleukin-8, Tumor necrosis factor-α were detected in venous blood serum. The functional state of the autonomic nervous system was assessed by R.M. Baevsky’s method of mathematical analysis of heart rate variability. The observation period is 1 and 10 days from the onset of stroke. <h3>Results:</h3> The subpopulation level of lymphocytes depends on the potential of the sympathetic spectrum of vegetal regulation; the indicators of humoral immunity have reciprocal dependencies with neurohumoral activity and parasympathetic regulation. In patients with ischemia in the left hemisphere in the acute period, 21% parameters of cardiointervalography and immunograms show significant correlations; in the acute period, the number of dependencies increased with an increase in sympathetic activity. In patients with stroke in the right hemisphere and in the vertebrobasilar basin in the most acute period, the number of significant correlations was 42%, which is 2 times more than in the first subgroup. In the acute period, with the growth of parasympathetic impact, the relations of the studied parameters reciprocally weaken and decrease. <h3>Conclusions:</h3> An unfavorable prognostic sign in patients with stroke living in low-mountain area is low values of CD3+, CD8+ cells and IL4, high CD16+, CD19+ cells, as well as a low level of neurohumoral and sympathetic regulation <b>Disclosure:</b> Nargiza Chekeeva has nothing to disclose.