Abstract
Numerous studies have established a close relationship between tumor progression, prognosis, and the infiltration of immune cells in the tumor microenvironment. This study aimed to investigate the differences in infiltrating immune cells between recurrent endometrial cancer and non-recurrent endometrial cancer. Firstly, gene expression data of endometrial cancer were obtained from the GEO database. Differential gene analysis using Geo2R identified significant gene expression differences, and KEGG and GO analyses were conducted on the qualified differential genes. Subsequently, CIBERSORT was employed to analyze the infiltration of 22 immune cell types in the tumor microenvironment, identifying differential immune cells. The results revealed significant differences in gene expression between recurrent and non-recurrent endometrial carcinoma. Interestingly, CIBERSORT analysis demonstrated a significant increase in monocyte infiltration in recurrent endometrial cancer compared to non-recurrent cases. Monocyte infiltration was found to play a crucial role in the progression of endometrial cancer recurrence. These findings provide valuable insights for clinicians to develop personalized treatment strategies for patients with recurrent endometrial cancer.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
