Abstract
Optogenetics combined with microelectrode array electrophysiology is a valuable tool set for the investigation of structure-function relations e.g. for understanding of human neurodegenerative diseases at microscale levels. We conducted long-term electrophysiology, full field and holographic single-neuron stimulation experiments using a fast ferroelectric modulator on in-vitro networks of iNGN cells derived from human fibroblasts expressing wild-type Channelrhodopsin2-EYFP. Functional maturation and successful ChR2-expression are observed in significant rises in action potential frequencies. Single neuron stimulation allows the extraction of functional connectivity maps, signal origins and post- or presynaptic signal characteristics as well as other modalities we will discuss in our presentation.
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