Correlation analysis of early coagulation and fibrinolysis changes with delayed intracranial hemorrhage in patients with craniocerebral injury

Abstract

Objective To analyze the correlation of early coagulation and fibrinolysis changes with delayed intracranial hemorrhage in patients with craniocerebral injury. Methods Eighty-three patients with simple brain injury from April 2013 to August 2015 were randomly selected according to whether the patients with delayed onset hematoma, and they were divided into observation group (delayed hematoma group, 27 cases) and control group (no hematoma, 56 cases). Recorded the platelet count (PLT), D- dimer (DD), prothrombin time (TT), fiber fibrinogen (Fg), activated partial thromboplastin time (APTT) and early prothrombin time (PT) and fibrin degradation products (FDP) level detection. The other 50 cases of healthy people were selected as healthy group. Observed and analyzed the early coagulation and fibrinolysis changes and occurrence of delayed intracranial hemorrhage of the two groups. Results The FDP, D-D, PT levels of observation group were significantly higher than those of control group, the plasma Fg levels was significantly lower than those of control group, the difference was significant (P<0.05). The FDP, D-D, APTT, PT of craniocerebral injury group were higher than those of healthy group, the Fg, PLT level of brain injury group were significantly lower than those of healthy group, the differences were significant (P<0.05). Conclusions The early coagulation changes in brain injury patients is ubiquitous. Detecting the early coagulation and fibrinolysis combined with cranial CT examination results can in order to evaluate the risk of delayed intracranial hemorrhage. Key words: Craniocerebral injury; Delayed intracranial hemorrhage; Early coagulation and fibrinolysis; Correlation