Abstract
Aim This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C (p < 0.05). ROC curve and multivariate logistic regression showed that the sensitivity and specificity of combined diagnosis of ACS with serum IL-18, MMP-9, hs-CRP, and plasma FIB were 86.03% and 95.71%, respectively. Serum IL-18, MMP-9, hs-CRP, and plasma FIB were positively correlated with Gensini grading (p < 0.001). Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels were positively correlated (p < 0.001). Conclusion The combined detection of serum IL-18, MMP-9, hs-CRP, and plasma FIB has good diagnostic value for ACS, and these index levels are positively correlated with the degree of vascular lesions.
Highlights
Coronary heart disease is a kind of stable or unstable disease, which can rapidly develop into acute coronary syndrome (ACS) within a few years, cause myocardial infarction, and lead to sudden death of patients [1]
matrix metalloproteinase-9 (MMP-9) is an enzyme analog that damages the elastic membrane of blood vessels and is closely related to atherosclerotic plaque and vascular reconstruction [24]. high-sensitivity C-reactive protein (hs-CRP) is an indicator of inflammatory state, and the level of hs-CRP can change with the characteristics of coronary plaque, which is a predictor of coronary disease-related mortality [25]
The levels of serum IL-18, MMP-9, hs-CRP, and plasma FIB in group A are significantly higher than those in groups B and C, which indicates that IL-18, MMP-9, hs-CRP, and FIB may participate in the occurrence and development of ACS, and is similar to the above research
Summary
Coronary heart disease is a kind of stable or unstable disease, which can rapidly develop into acute coronary syndrome (ACS) within a few years, cause myocardial infarction, and lead to sudden death of patients [1]. ACS is defined as ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UAP). ACS is a serious manifestation of cardiovascular diseases and is one of the major diseases with high mortality in the world including China [2]. The diagnosis of ACS mainly depends on electrocardiogram, clinical symptoms, and biochemical markers. Patients with ACS often have poor prognosis if they are not treated in time [3]. The timely diagnosis and evaluation of ACS is of great significance for subsequent treatment
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