Correlation analysis between vitamin D and ovarian reserve markers in infertile women

Abstract

Objective To investigate the relationship between serum vitamin D levels and ovarian reserve markers anti-Mullerian hormone (AMH) or antral follicle count (AFC). Methods Totally 2 391 cases infertility patients who received assisted reproductive technology for the first time were retrospectively analysed.According to the serum 25(OH)D3 level, they were divided into ≤30 nmol/L group (group A, n=417), 30.1- 49.9 nmol/L group (group B, n=626), ≥50 nmol/L group (group C, n=1 348). The relationship were analysed between serum 25(OH)D3 levels and AMH or AFC among the above three groups. Results 1) There was no significant difference in age, BMI, basic FSH, infertility cause and vitamin D level in different seasons among the three groups (P>0.05). 2) There was no significant difference in AMH mean level [(4.07±3.53) ng/mL, (4.12±3.43) ng/mL and (4.10±3.18) ng/mL, respectively] and AFC (14.0±6.7, 13.7±5.9 and 14.1±6.1, respectively) among the three groups (P>0.05). 3) After adjusting the potential confounding factors, we used the multivariate linear regression analysis and found that there was no correlation between AMH (B=-0.005, sx=0.007, P=0.506) or AFC (B=-0.122, sx=0.019, P=0.214) and serum 25(OH)D3 level (P>0.05). Conclusion There was no correlation between serum vitamin D and ovarian reserve marker AMH or AFC for infertile women. For infertile women lacking vitamin D, it may have no effects on improving ovarian reserve function by supplementing vitamin D. Key words: Vitamin D; Ovarian reserve markers; Anti-Mullerian hormone (AMH); Antral follicle count (AFC)