Abstract
Objective To explore the correlation between the resistance characteristics of Helicobacter pylori (HP) and antibiotic use density (AUD) in a hospital from 2012 to 2018. Methods HP strains isolated from Chinese PLA General Hospital from 2012 to 2018 were collected to analyze the drug resistance of clarithromycin, levofloxacin, amoxicillin, and metronidazole, and their correlation with the AUD of the outpatient department and inpatient department was analyzed, respectively. Results From 2012 to 2018, metronidazole-resistant strains accounted for the largest proportion, followed by clarithromycin and levofloxacin, and amoxicillin-resistant strains accounted for the least. In 2012–2018, the resistance rate of clarithromycin, levofloxacin, amoxicillin, and metronidazole has basically increased year by year; from 2012 to 2018, the highest outpatient AUD in a hospital was amoxicillin, followed by clarithromycin and levofloxacin, metronidazole was the lowest, and the inpatient AUD from high to low was levofloxacin, metronidazole, amoxicillin, and clarithromycin. The drug resistance rate of HP in the hospital from 2012 to 2018 was positively correlated with the AUD of clarithromycin (r = 0.884, P=0.017) and levofloxacin (r = 0.934, P=0.002) in the outpatient department. Conclusions Helicobacter pylori has the strongest resistance to metronidazole and the worst resistance to amoxicillin in the hospital from 2012 to 2018, being related to the intensity of clarithromycin and levofloxacin in the outpatient department. It may provide certain reference significance for the clinical treatment of Helicobacter pylori.
Highlights
Helicobacter pylori (HP), a kind of ubiquitous Gram-negative and spiral-shaped bacterium, was first identified by Marshall and Warren in 1982
There are relatively few studies on the clinical change characteristics of HP infection and different correlations between different antibiotics and the resistance mode, warranting further in-depth investigations. us, this study investigated the characteristics of HP injection in a hospital from 2012 to 2018 and used the Pearson correlation coefficient to analyze the correlation between Hp resistance and antibiotic use density (AUD) in the outpatient department and inpatient department, respectively, to provide a reference for the rational use of antibiotics
Clarithromycin increased from 15.71% in 2012 to 24.69% in 2018, levofloxacin from 12.86% in 2012 to 22.22% in 2018, and amoxicillin from 1.43% in 2012 to 4.94% in 2018
Summary
Helicobacter pylori (HP), a kind of ubiquitous Gram-negative and spiral-shaped bacterium, was first identified by Marshall and Warren in 1982. HP is the common pathogenic factor of gastrointestinal diseases, such as peptic ulcer and gastritis, and an independent risk factor of gastric cancer, being a serious threat to human health [3]. Some scholars believe that both the characteristics of pathogens and drugs and the antibiotic use density (AUD), social economy, and management mode all contribute to the drug resistance of the pathogen [6]. There are relatively few studies on the clinical change characteristics of HP infection and different correlations between different antibiotics and the resistance mode, warranting further in-depth investigations. Us, this study investigated the characteristics of HP injection in a hospital from 2012 to 2018 and used the Pearson correlation coefficient to analyze the correlation between Hp resistance and AUD in the outpatient department and inpatient department, respectively, to provide a reference for the rational use of antibiotics
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