Abstract
BackgroundTo explore the correlation between the preoperative systemic immune inflammation index (SII) and the prognosis of patients with gastric carcinoma (GC).MethodsThe clinical data of 771 GC patients surgically treated in the Department of Gastrointestinal Surgery, Qinghai University Affiliated Hospital from June 2010 to June 2015 were retrospectively analyzed, and their preoperative SII was calculated. The optimal cut-off value of preoperative SII was determined using the receiver operating characteristic (ROC) curve, the confounding factors between the two groups were eliminated using the propensity score matching (PSM) method, and the correlation between preoperative SII and clinicopathological characteristics was assessed by chi-square test. Moreover, the overall survival was calculated using Kaplan-Meier method, the survival curve was plotted, and log-rank test was performed for the significance analysis between the curves. Univariate and multivariate analyses were also conducted using the Cox proportional hazards model.ResultsIt was determined by the ROC curve that the optimal cut-off value of preoperative SII was 489.52, based on which 771 GC patients were divided into high SII (H-SII) group and low SII (L-SII) group, followed by PSM in the two groups. The results of Kaplan-Meier analysis showed that before and after PSM, the postoperative 1-, 3-, and 5-year survival rates in L-SII group were superior to those in H-SII group, and the overall survival rate had a statistically significant difference between the two groups (P < 0.05). Before PSM, preoperative SII [hazard ratio (HR) = 2.707, 95% confidence interval (CI) 2.074-3.533, P < 0.001] was an independent risk factor for the prognosis of GC patients. After 1:1 PSM, preoperative SII (HR = 2.669, 95%CI 1.881–3.788, P < 0.001) was still an independent risk factor for the prognosis of GC patients.ConclusionsPreoperative SII is an independent risk factor for the prognosis of GC patients. The increase in preoperative SII in peripheral blood indicates a worse prognosis.
Highlights
Gastric carcinoma (GC) is a common digestive tract malignancy
General data A total of 771 patients met the screening criteria, including 165 females (21.40%) and 606 males (78.60%), with a Correlation between systemic immune inflammation index (SII) and clinicopathological factors of gastric carcinoma (GC) patients before and after propensity score matching (PSM) Before matching, SII was related to the maximum diameter of tumor, histological type, serum albumin (ALb), Fig. 1 Study flow diagram white blood cell (WBC), carbohydrate antigen 125 (CA125), and TNM stage (P < 0.05), but not related to the age, gender, smoking, drinking, carcinoembryonic antigen (CEA), CA199, and operation method (P > 0.05)
PSM was performed in low SII (L-SII) group and high SII (H-SII) group, and a total of 354 patients were eligible, including 177 cases in H-SII group and 177 cases in L-SII group
Summary
Gastric carcinoma (GC) is a common digestive tract malignancy. In 2018, there were up to 782,000 deaths of GC, making it the third cause of death in malignancies [1]. Tumorinduced inflammatory response can cause corresponding changes in the blood neutrophil (NE), lymphocyte (LY), and platelet (PLT) counts [6,7,8]. On this basis, some studies have tried to discover new potential biomarkers related to the prognosis. The preoperative systemic immune inflammation index (SII) calculated based on NE, LY, and PLT is correlated with the prognosis of breast cancer, liver cancer and pancreatic cancer [9,10,11,12]. To explore the correlation between the preoperative systemic immune inflammation index (SII) and the prognosis of patients with gastric carcinoma (GC)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
