Abstract
BackgroundUterine fibroids(UF) are the most common benign tumors in women, with high incidence and unknown causes. We aimed to explore the correlation between Methylenetetra-hydrofolate reductase (MTHFR) C677T polymorphism and UF.MethodsThis is a retrospective cohort study. Data were collected from 2411 women detected for MTHFR C677T polymorphism in the Fifth Affiliated Hospital of Sun Yat-sen University from 2018 to 2020. B-ultrasound (BU) and the first page of medical records were used to analyze whether they had ever been diagnosed with UF. The collected data were analyzed. Using the chi-square test and regression analysis to explore the correlation, and the risk factors was screened by multifactor logistic regression analysis.ResultsA total of 2411 pregnant women were in the MTHFR C677T polymorphism detection. Among them, 226(9.37%) were diagnosed as UF by BU or clinical diagnosis. The allele and genotype of MTHFR C677T were significantly different between the case and control group (p<0.05), and the distribution of the allele was following Hardy-Weinberg (H-W) equilibrium. Comparing with the wild-type (C/C), the mutant group (C/T+T/T) was more likely to form UF(OR,1.43;OR95%CI,1.07-1.89). After adjusting for confoundings, the heterozygous mutant (C/T) was more susceptible to UF than the wild-type (aOR,1.41;aOR95%CI,1.41-1.91). In the case group, BMI, gravidity and parity were not associated with the size and number of UF and the MTHFR C677T polymorphism (p>0.05). However, older maternal age was associated with the incidence of UF, especially the multiple UF (p<0.05).ConclusionOur results found that MTHFR C677T polymorphism was associated with UF occurrence for the first time. This could imply that it may increase the risk of forming UF in women of gestational age.
Highlights
Uterine fibroids (UF), originating from the Smooth muscle layer of the uterus and are composed of Smooth muscle cells (SMC) and connective tissue, are the most common benign tumour in gynecology with specific hereditary characteristics [1]
A total of 2411 women were detected for peripheral blood Methylenetetra-hydrofolate reductase (MTHFR) C677T polymorphism and 226(9.73%) women who had been clinically and ultrasonically diagnosed with UF
The size and number of UF correlated with MTHFR C677T polymorphism (p
Summary
Uterine fibroids (UF), originating from the Smooth muscle layer of the uterus and are composed of Smooth muscle cells (SMC) and connective tissue, are the most common benign tumour in gynecology with specific hereditary characteristics [1] They are highly prevalent, the incidence is as high as 70% and more common in women of childbearing age, and most of them are asymptomatic, and the rate of malignant degeneration is low. It often causes abnormal uterine bleeding, secondary anemia, pelvic organ pressure, infertility and pregnancy. We aimed to explore the correlation between Methylenetetra-hydrofolate reductase (MTHFR) C677T polymorphism and UF
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