Correlation analysis between exhaled nitric oxide and allergen sIgE in asthmatic patients

Abstract

Objective To explore the correlation between the level of excreted nitric oxide (FeNO) and specific IgE (sIgE) in patients with bronchial asthma (asthma). Methods Select 118 cases of asthma patients in our hospital during March 2017 to April 2018 as studying object, FeNO, allergen sIgE and total IgE levels were detected.The patients were divided into FeNO-positive group and FeNO-negative group according to the level of FeNO detection.The fungal allergens sIgE, sIgE and total IgE levels in the two groups were compared and analyzed by Pearson.Correlation between FeNO and allergen sIgE. Results There was no significant difference in the level of sIgE between the FeNO-positive group and the FeNO-negative group (t=1.077 1, P>0.05). The levels of sIgE and total IgE in the FeNO-positive group were significantly higher than those in the FeNO-negative group (t=5.741 1, 8.894 8, both P 0.05). There was a positive correlation between FeNO and the allergen sIgE (r=0.742, P 200 U/ml FeNO(75.3±5.5) ppb; FeNO levels were (75.3±5.5) ppb (t=29.809 9, 33.718 5, both P 200 U/ml (t=7.5138, P<0.01). Conclusions There is a clear correlation between FeNO and allergen sIgE in asthma patients. Key words: Asthma; Nitric oxide; Allergens; Relevance