Abstract
Introduction: Colon cancer is one of the common cancers in the world. Despite current advances in the treatments of cancer, the clinical result is far away from expectation yet. Drug resistance is still a major obstacle in treatment of cancer .In this study, we attempted to investigate the possible correlation among MRP1, MRP and hTERT expression level and multidrug resistance in colon cancer patients. Materials and Methods: Tumor and adjacent normal tissues from 35 colorectal cancer patients were assessed for the mRNA expression level of MDR1, MRP and hTERT by Real Time RT-PCR. Results: A statistically significant increase in MDR1 and hTERT expression level was observed in tumoral tissues in comparison with normal tissues. However MRP expression level was not significantly increased in tumoral tissues. Furthermore, no correlation was seen among MDR1, MRP and hTERT expression level. Conclusion: MDR1 and hTERT have no direct correlation, but mRNA expression of these two genes in addition to other factors indirectly helps to tumorgenesis and cancer progression.
Highlights
Colon cancer is one of the common cancers in the world
Multidrug resistance1 (MDR1) and hTERT have no direct correlation, but mRNA expression of these two genes in addition to other factors indirectly helps to tumorgenesis and cancer progression
The results indicated there was no correlation between MDR1/hTERT, multidrug resistance-associated protein (MRP)/ hTERT and multi drug resistance (MDR)/MRP expression levels
Summary
Colon cancer is one of the common cancers in the world. Despite current advances in the treatments of cancer, the clinical result is far away from expectation yet. Drug resistance is still a major obstacle in treatment of cancer .In this study, we attempted to investigate the possible correlation among MRP1, MRP and hTERT expression level and multidrug resistance in colon cancer patients. Several mechanisms for drug resistance have been suggested including mutation and over expression of the drug’s target, inactivation and efflux the drug from the cell by ATP Binding Cassette transporters [3]. MDR1 protein or P-gp is a transmembrane glycoprotein with molecular weight of 170 kDa, encodes by MDR gene. It transports many hydrophobic substrates and anti-cancer drugs including etoposide, doxorubicin and vinblastine [6,7]
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