Abstract
Objective: To investigate the correlation among CD4+CD25+ Treg cell frequency, CTLA-4 expression level in the peripheral blood mononuclear cells (PBMC), and disease progression of HIV/AIDS patents. Methods: Fifty HIV/AIDS-positive samples were confirmed by both Zhejiang Provincial and Hangzhou Center for Disease Control and Prevention. Ten samples of healthy volunteers were randomly selected as controls. Immune cells were counted using a flow cytometer (FACS), and the expression level of CTLA-4 mRNA analyzed using RT-PCR. Results: CD4+CD25+ Treg cells in PBMC of HIV/AIDS patients were markedly higher than those of healthy volunteers£ ̈P = 0.04j, and CTLA-4 mRNA was highly expressed in the CD4+CD25+ Treg subpopulation (P = 0.002), compared to healthy adults as well as AIDS patients treated with HAART. Conclusion: CTLA-4 expressed on CD4+CD25+ Treg cells can be a specific marker of the progression of HIV/AIDS, and the inhibitory receptor may play an important role in the regulation and pathogenesis of HIV/AIDS.
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