CORRELATING CLINICAL CHARACTERISTICS OF COLORECTAL CANCER PATIENTS IN VIETNAM WITH MUTATIONAL ANALYSIS OF EXON 2 OF KRAS GENE

Abstract

Colorectal cancer is a major cause of cancer-related deaths globally, and the disease arises from genetic mutations that impair cellular signaling pathways involved in proliferation, differentiation, and apoptosis. This study aimed to determine the prevalence, describe, and establish the correlation between different types of KRAS exon 2 mutations in patients with colorectal cancer. The study used a cross-sectional investigation on a cohort of 77 patients who underwent treatment for colorectal adenocarcinoma and had confirmed surgical tissue samples. The study found that KRAS gene mutations were in 39.0% of patients, with G12D are the most prevalent mutation. The study also found a significant correlation between KRAS exon 2 mutations and anemia, platelet count and CEA levels. The research results suggest that KRAS exon 2 mutations are prevalent in Vietnamese patients with colorectal cancer and that these mutations may be useful biomarkers for predicting disease progression and survival. Further studies are needed to investigate the functional consequences of these mutations and explore potential targeted therapies for patients with KRAS mutations. Overall, this study provides important insights into the genetic basis of colorectal cancer in Vietnamese patients and may inform future research on improving diagnosis and treatment outcomes for this disease. Keywords: Colorectal Cancer, Exon 2 Gene Mutations, KRAS Gene, SNP DOI： https://doi.org/10.35741/issn.0258-2724.58.3.1